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[8] One such potential pathway involves the activation of phospholipase C (PLC), which researchers suggest may lead to the release of inositol triphosphate (IP3) and diacylglycerol (DAG)

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ALCAR and KET also activated brainstem nuclei (locus coeruleus, diagonal band, and raphe nuclei) which send aminergic projections to cortical areas and spinal dorsal horns that are involved in pain and mood control (Freo et al., 2010

"Primary and secondary red ear syndrome: implications for treatment"